abstract：:Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...

journal_title：Human pathology

authors： Charbonneau B,Vogel RI,Manivel JC,Rizzardi A,Schmechel SC,Ognjanovic S,Subramanian S,Largaespada D,Weigel B

更新日期：2013-09-01 00:00:00

abstract：:Although adipophilin has been reported to be a sensitive marker for sebaceous carcinoma, others have noted its expression in squamous cell carcinoma and a variety of noncutaneous tumors, suggesting that lipid droplet accumulation is a frequent feature of neoplastic cells. We investigated the expression of adipophilin ...

journal_title：Human pathology

authors： Boussahmain C,Mochel MC,Hoang MP

更新日期：2013-09-01 00:00:00

abstract：:Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...

journal_title：Human pathology

authors： Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto M

更新日期：2013-09-01 00:00:00

abstract：:Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present st...

journal_title：Human pathology

authors： Mathai AM,Alexander J,Kuo FY,Torbenson M,Swanson PE,Yeh MM

更新日期：2013-08-01 00:00:00

abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...

journal_title：Human pathology

authors： Scantlebury JB,Luo J,Thorstad WL,El-Mofty SK,Lewis JS Jr

更新日期：2013-08-01 00:00:00

abstract：:Insulin-like growth factor-II messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is a biomarker whose expression has been found to be a negative prognostic factor in several neoplasms including ovarian clear cell carcinoma (CCC). In this study, we analyzed the frequency and clinicopathologic significance of IMP3 expres...

journal_title：Human pathology

authors： Fadare O,Liang SX,Crispens MA,Jones HW 3rd,Khabele D,Gwin K,Zheng W,Mohammed K,Parkash V,Hecht JL,Desouki MM

更新日期：2013-08-01 00:00:00

abstract：:Micropapillary carcinoma of the breast is associated with increased rates of lymph node metastasis and lymphovascular invasion. While activating point mutations in PIK3CA (encoding phosphatidylinositol-3-kinase catalytic subunit) or AKT1 are found in 25% to 30% of invasive ductal carcinomas, the mutational profile of ...

journal_title：Human pathology

authors： Flatley E,Ang D,Warrick A,Beadling C,Corless CL,Troxell ML

更新日期：2013-07-01 00:00:00

abstract：:Promyelocytic leukemia zinc finger is a zinc finger transcription factor that functions as a transcriptional repressor. Its expression has been shown to be down-regulated in hematopoietic, melanocytic, and mesothelial malignancies. Histone H1.5 is a variant of histone H1, a family of linker proteins that organizes chr...

journal_title：Human pathology

authors： Hechtman JF,Beasley MB,Kinoshita Y,Ko HM,Hao K,Burstein DE

更新日期：2013-07-01 00:00:00

abstract：:Follicular dendritic cells (FDCs) are a specialized type of antigen-presenting dendritic cells that are largely restricted to lymphoid follicles. They form dense three-dimensional meshwork patterns within benign follicles, which maintain the follicular architecture. The FDC function is to bind and retain antigens by l...

journal_title：Human pathology

authors： Rezk SA,Nathwani BN,Zhao X,Weiss LM

更新日期：2013-06-01 00:00:00

abstract：:Plasmacytoid dendritic cells, which play a fundamental role in the innate immune response, are best known for their presence in hyaline-vascular Castleman disease and histiocytic necrotizing lymphadenitis. The relative number and distribution in many reactive entities as detected using more sensitive methods are uncer...

journal_title：Human pathology

authors： Rollins-Raval MA,Marafioti T,Swerdlow SH,Roth CG

更新日期：2013-06-01 00:00:00

abstract：:It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...

journal_title：Human pathology

authors： Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL

更新日期：2013-05-01 00:00:00

abstract：:Alterations of the epidermal growth factor receptor (EGFR) can be observed in a significant subset of esophageal adenocarcinomas (EACs), and targeted therapy against EGFR may become an interesting approach for the treatment of these tumors. Mutations of KRAS, NRAS, BRAF, and phosphatidylinositol-3-kinase catalytic sub...

journal_title：Human pathology

authors： Bettstetter M,Berezowska S,Keller G,Walch A,Feuchtinger A,Slotta-Huspenina J,Feith M,Drecoll E,Höfler H,Langer R

更新日期：2013-05-01 00:00:00

abstract：:Despite an overall decrease in colorectal carcinoma incidence, rates of colorectal carcinoma have increased substantially in patients aged less than 40 years. Several authors have characterized morphologic features of colorectal carcinoma in young patients, with variable results. To date, there has been 1 detailed mol...

journal_title：Human pathology

authors： Kenney B,Deng Y,Mitchell K

更新日期：2013-04-01 00:00:00

abstract：:The current World Health Organization classification considers myelodysplastic syndrome with isolated del(5q) a distinct entity owing to its characteristic clinical and pathologic features. Recently, several studies have examined survival, leukemic transformation, and various prognostic factors in these patients. Howe...

journal_title：Human pathology

authors： Geyer JT,Verma S,Mathew S,Wang YL,Racchumi J,Espinal-Witter R,Subramaniyam S,Knowles DM,Orazi A

更新日期：2013-03-01 00:00:00

abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...

journal_title：Human pathology

authors： Yu J,Monaco SE,Onisko A,Bhargava R,Dabbs DJ,Cieply KM,Fine JL

更新日期：2013-03-01 00:00:00

abstract：:Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...

journal_title：Human pathology

authors： Fitzpatrick-Swallow VL,Helin H,Cane P,Pinder SE

更新日期：2013-01-01 00:00:00

abstract：:Hypertrophic cardiomyopathy phenotype is shared by heterogeneous entities. The purpose of the study was to evaluate the diagnostic role of left ventricular endomyocardial biopsy. One hundred fifty-one consecutive patients with unexplained left ventricular hypertrophy and normal/elevated QRS voltages or left bundle-bra...

journal_title：Human pathology

authors： Frustaci A,Russo MA,Chimenti C

更新日期：2013-01-01 00:00:00

abstract：:Immunoglobulin G4-related sclerosing cholangitis is histologically characterized by the infiltration of immunoglobulin G4-positive plasma cells and sclerosing change. Moreover, several cases of carcinoma accompanied by immunoglobulin G4-positive cells in tissue and increased serum immunoglobulin G4 levels have been re...

journal_title：Human pathology

authors： Kimura Y,Harada K,Nakanuma Y

更新日期：2012-12-01 00:00:00

abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...

journal_title：Human pathology

authors： Tsang JY,Mendoza P,Putti TC,Karim RZ,Scolyer RA,Lee CS,Pang AL,Tse GM

更新日期：2012-12-01 00:00:00

abstract：:Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained for GATA binding protein 3...

journal_title：Human pathology

authors： Miyamoto H,Izumi K,Yao JL,Li Y,Yang Q,McMahon LA,Gonzalez-Roibon N,Hicks DG,Tacha D,Netto GJ

更新日期：2012-11-01 00:00:00

abstract：:Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...

journal_title：Human pathology

authors： Magro G,Righi A,Casorzo L,Antonietta T,Salvatorelli L,Kacerovská D,Kazakov D,Michal M

更新日期：2012-11-01 00:00:00

abstract：:DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a series of 94 Tunisian sporadic breast carcinomas. Re...

journal_title：Human pathology

authors： Ben Gacem R,Hachana M,Ziadi S,Ben Abdelkarim S,Hidar S,Trimeche M

更新日期：2012-10-01 00:00:00

abstract：:An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...

journal_title：Human pathology

authors： Cornejo K,Shi M,Jiang Z

更新日期：2012-10-01 00:00:00

abstract：:Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but und...

journal_title：Human pathology

authors： Lino-Silva LS,Domínguez-Malagón HR,Caro-Sánchez CH,Salcedo-Hernández RA

更新日期：2012-10-01 00:00:00

abstract：:Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating t...

journal_title：Human pathology

authors： Rakheja D,Konoplev S,Medeiros LJ,Chen W

更新日期：2012-10-01 00:00:00

abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...

journal_title：Human pathology

authors： Zhang J,Chang DY,Mercado-Uribe I,Liu J

更新日期：2012-09-01 00:00:00

abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...

journal_title：Human pathology

authors： Conces MR,Williamson SR,Montironi R,Lopez-Beltran A,Scarpelli M,Cheng L

更新日期：2012-09-01 00:00:00

abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...

journal_title：Human pathology

authors： Jaso J,Chen L,Li S,Lin P,Chen W,Miranda RN,Konoplev S,Medeiros LJ,Yin CC

更新日期：2012-09-01 00:00:00

abstract：:Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...

journal_title：Human pathology

authors： Yang L,Chen Y,Cui T,Knösel T,Zhang Q,Geier C,Katenkamp D,Petersen I

更新日期：2012-09-01 00:00:00

abstract：:The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...

journal_title：Human pathology

authors： Cates JM,Black J,Wolfe CC,Shinohara ET,Holt GE,Keedy VL,Hande KR,Homlar KC,Halpern JL,Schwartz HS,Troutman A,Coffin CM

更新日期：2012-09-01 00:00:00

abstract：:Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...

journal_title：Human pathology

authors： Matsuoka K,Hayashi S,Urano F,Zhu LJ,Okita H,Sago H,Nakazawa A

更新日期：2012-09-01 00:00:00

abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...

journal_title：Human pathology

authors： MacQuarrie E,Arnason T,Gruchy J,Yan S,Drucker A,Huang WY

更新日期：2012-08-01 00:00:00

abstract：:Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...

journal_title：Human pathology

authors： Cheng Y,Zhou Y,Jiang W,Yang X,Zhu J,Feng D,Wei Y,Li M,Yao F,Hu W,Xiao W,Ling B

更新日期：2012-08-01 00:00:00

abstract：:The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin 5γ2, and SMAD4 and their relationship to survival were studied in different tumor areas, namely, tumor center and invasive fron...

journal_title：Human pathology

authors： García-Solano J,Conesa-Zamora P,Trujillo-Santos J,Torres-Moreno D,Mäkinen MJ,Pérez-Guillermo M

更新日期：2012-07-01 00:00:00

abstract：:Tumor budding is an acknowledged prognostic marker in colorectal cancer. This study was conducted to investigate the morphology and prognostic significance of budding in rectal cancer after neoadjuvant radiotherapy. Surgical specimens from 96 consecutive patients who underwent neoadjuvant radiotherapy and curative res...

journal_title：Human pathology

authors： Du C,Xue W,Li J,Cai Y,Gu J

更新日期：2012-07-01 00:00:00

abstract：:The aim of this study was to systematically investigate clinicopathologic features of the recently described pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus (n = 43). Patient median age was 66 years (range, 51-90 years). The male-to-female ratio was 7.6. Grossly, pancreatic acinar-...

journal_title：Human pathology

authors： Huang Q,Gold JS,Shi J,Fan X,Wu H,Feng A,Zhou Q

更新日期：2012-06-01 00:00:00

abstract：:Total parenteral nutrition (TPN) therapy is a well-recognized cause of liver injury. The histologic changes attributed to TPN in the literature vary widely. In this study, we describe the histopathologic changes associated with TPN therapy and relate these changes to various clinical parameters. We conducted a retrosp...

journal_title：Human pathology

authors： Naini BV,Lassman CR

更新日期：2012-06-01 00:00:00

abstract：:Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...

journal_title：Human pathology

authors： Flucke U,Mentzel T,Verdijk MA,Slootweg PJ,Creytens DH,Suurmeijer AJ,Tops BB

更新日期：2012-05-01 00:00:00

abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...

journal_title：Human pathology

authors： Canet B,Pons C,Espinosa I,Prat J

更新日期：2012-05-01 00:00:00

abstract：:Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...

journal_title：Human pathology

authors： Dhall D,Mertens R,Bresee C,Parakh R,Wang HL,Li M,Dhall G,Colquhoun SD,Ines D,Chung F,Yu R,Nissen NN,Wolin E

更新日期：2012-04-01 00:00:00